Article
Genome-wide association study identifies multiple susceptibility loci for glioma.
Nature communications - 1 Oct 2015
Kinnersley Ben, Labussière Marianne, Holroyd Amy, Di Stefano Anna-Luisa, Broderick Peter, Vijayakrishnan Jayaram, Mokhtari Karima, Delattre Jean-Yves, Gousias Konstantinos, Schramm Johannes, Schoemaker Minouk J, Fleming Sarah J, Herms Stefan, Heilmann Stefanie, Schreiber Stefan, Wichmann Heinz-Erich, Nöthen Markus M, Swerdlow Anthony, Lathrop Mark, Simon Matthias, Bondy Melissa, Sanson Marc, Houlston Richard S
Abstract excerpt
Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new...
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