Article
Quantifying the heritability of glioma using genome-wide complex trait analysis.
Scientific reports - 2 Dec 2015
Kinnersley Ben, Mitchell Jonathan S, Gousias Konstantinos, Schramm Johannes, Idbaih Ahmed, Labussière Marianne, Marie Yannick, Rahimian Amithys, Wichmann H-Erich, Schreiber Stefan, Hoang-Xuan Khe, Delattre Jean-Yves, Nöthen Markus M, Mokhtari Karima, Lathrop Mark, Bondy Melissa, Simon Matthias, Sanson Marc, Houlston Richard S
Abstract excerpt
Genome-wide association studies (GWAS) have successfully identified a number of common single-nucleotide polymorphisms (SNPs) influencing glioma risk. While these SNPs only explain a small proportion of the genetic risk it is unclear how much is left to be detected by other, yet to be identified, common SNPs. Therefore, we applied Genome-Wide Complex Trait Analysis (GCTA) to three GWAS datasets totalling 3,373...
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