Article
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
Nature genetics - 1 May 2017
Melin Beatrice S, Barnholtz-Sloan Jill S, Wrensch Margaret R, Johansen Christoffer, Il'yasova Dora, Kinnersley Ben, Ostrom Quinn T, Labreche Karim, Chen Yanwen, Armstrong Georgina, Liu Yanhong, Eckel-Passow Jeanette E, Decker Paul A, Labussière Marianne, Idbaih Ahmed, Hoang-Xuan Khe, Di Stefano Anna-Luisa, Mokhtari Karima, Delattre Jean-Yves, Broderick Peter, Galan Pilar, Gousias Konstantinos, Schramm Johannes, Schoemaker Minouk J, Fleming Sarah J, Herms Stefan, Heilmann Stefanie, Nöthen Markus M, Wichmann Heinz-Erich, Schreiber Stefan, Swerdlow Anthony, Lathrop Mark, Simon Matthias, Sanson Marc, Andersson Ulrika, Rajaraman Preetha, Chanock Stephen, Linet Martha, Wang Zhaoming, Yeager Meredith, Wiencke John K, Hansen Helen, McCoy Lucie, Rice Terri, Kosel Matthew L, Sicotte Hugues, Amos Christopher I, Bernstein Jonine L, Davis Faith, Lachance Dan, Lau Ching, Merrell Ryan T, Shildkraut Joellen, Ali-Osman Francis, Sadetzki Siegal, Scheurer Michael, Shete Sanjay, Lai Rose K, Claus Elizabeth B, Olson Sara H, Jenkins Robert B, Houlston Richard S, Bondy Melissa L
Abstract excerpt
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1...
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