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Article

Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.

British journal of cancer - 1 Jan 2021

Saunders Charlie N, Cornish Alex J, Kinnersley Ben, Law Philip J, Houlston Richard S

Abstract excerpt

BACKGROUND: The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors. METHODS: We performed an MR-PheWAS analysing 316 phenotypes, proxied by 8387 genetic variants, and summary genetic data from a GWAS of 12,488 glioma cases and 18,169 controls....

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Identifiers

PMID: 33020596
DOI: 10.1038/s41416-020-01083-1
PMCID: PMC7852872

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