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Association of polygenic liabilities for schizophrenia and bipolar disorder with educational attainment and cognitive aging.

Translational psychiatry - 16 Nov 2024

Wu Chi-Shin, Hsu Chia-Lin, Lin Mei-Chen, Su Mei-Hsin, Lin Yen-Feng, Chen Chia-Yen, Hsiao Po-Chang, Pan Yi-Jiun, Chen Pei-Chun, Huang Yen-Tsung, Wang Shi-Heng

Abstract excerpt

To elucidate the specific and shared genetic background of schizophrenia (SCZ) and bipolar disorder (BPD), this study explored the association of polygenic liabilities for SCZ and BPD with educational attainment and cognitive aging. Among 106,806 unrelated community participants from the Taiwan Biobank, we calculated the polygenic risk score (PRS) for SCZ (PRSSCZ) and BPD (PRSBPD), shared PRS between SCZ and BPD...

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Identifiers

PMID: 39550361
DOI: 10.1038/s41398-024-03182-6
PMCID: PMC11569198

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