Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.

Psychological medicine - 30 Oct 2025

Hyat Mahnoor, Zhu Jinhan, Boltz Toni A, Conomos Matthew P, Hughes Dylan E, Fohner Alison E, Foster Katherine T, Bigdeli Tim B, Forsyth Jennifer K

Abstract excerpt

BACKGROUND: Subtle behavioral and cognitive symptoms precede schizophrenia (SCZ) and appear in individuals with elevated risk based on polygenic risk scores (SCZ-PRS) and family history of psychosis (SCZ-FH). However, most SCZ-PRS studies focus on European ancestry youth, limiting generalizability. Furthermore, it remains unclear whether SCZ-FH reflects common-variant polygenic risk or broader SCZ liability....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to European People

Share to Multifactorial Inheritance

Share to Psychotic Disorders

Share to Schizophrenia

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 41165094
DOI: 10.1017/S0033291725102304
PMCID: PMC13054910

Genes

FH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.PMID 41165094Read ↗

Unique prediction of developmental psychopathology from genetic and familial riskSemantic proximity Read ↗

Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study.Semantic proximity Read ↗

Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives, and Healthy Participants.Semantic proximity Read ↗

Genetic and clinical analyses of psychosis spectrum symptoms in a large multi-ethnic youth cohort reveal significant link with ADHDSemantic proximity Read ↗

Use of multiple Polygenic Risk Scores for distinguishing Schizophrenia-spectrum disorder and Affective psychosis categories; the EUGEI studySemantic proximity Read ↗

Exploring the Behavioral and Emotional Manifestation of Polygenic Risk for Psychiatric Disorders Among Schoolchildren.Semantic proximity Read ↗

Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population.Semantic proximity Read ↗

Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.Semantic proximity Read ↗

Polygenic prediction of the phenome, across ancestry, in emerging adulthood.Semantic proximity Read ↗

Unique prediction of developmental psychopathology from genetic and familial risk.Semantic proximity Read ↗

Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls.Semantic proximity Read ↗

Polygenic risk scores lack prognostic value for adults with severe mental illnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.