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Article

Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 Nov 2024

Hayashi Samantha Y, Pak Steven, Torlentino Antonio, Rizzo Robert C, Miller W Todd

Abstract excerpt

Mitogen-inducible gene 6 (Mig6) is a cellular inhibitor of epidermal growth factor receptor (EGFR) that binds directly to the EGFR kinase domain and interferes with signaling. Reduced Mig6 expression is correlated with increased EGFR activity in multiple cancer models. Here, we investigated whether disease-associated point mutations could reduce the inhibitory potency of Mig6. We show that several...

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PMID: 39548957
DOI: 10.1096/fj.202401330R

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Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor.PMID 39548957Read ↗

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