Article
Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.
BMC systems biology - 18 Feb 2011
Naruo Yoshimi, Nagashima Takeshi, Ushikoshi-Nakayama Ryoko, Saeki Yuko, Nakakuki Takashi, Naka Takashi, Tanaka Hiroshi, Tsai Shih-Feng, Okada-Hatakeyama Mariko
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) signaling plays an important role in the regulation of cell proliferation, survival, metastasis, and invasion in various tumors. Earlier studies showed that the EGFR is frequently overexpressed in non-small-cell lung cancer (NSCLC) and EGFR muta...
Topics
- Adaptor Proteins, Signal Transducing
- Blotting, Western
- Cell Line, Tumor
- Computational Biology
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- ErbB Receptors
- Gefitinib
- Humans
- Models, Biological
- Mutation
- Phosphorylation
- Quinazolines
- Signal Transduction