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Article

Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.

BMC systems biology - 18 Feb 2011

Naruo Yoshimi, Nagashima Takeshi, Ushikoshi-Nakayama Ryoko, Saeki Yuko, Nakakuki Takashi, Naka Takashi, Tanaka Hiroshi, Tsai Shih-Feng, Okada-Hatakeyama Mariko

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) signaling plays an important role in the regulation of cell proliferation, survival, metastasis, and invasion in various tumors. Earlier studies showed that the EGFR is frequently overexpressed in non-small-cell lung cancer (NSCLC) and EGFR mutations at specific amino acid residues in the kinase domain induce altered responsiveness to gefitinib, a small molecule...

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PMID: 21333004
DOI: 10.1186/1752-0509-5-29
PMCID: PMC3224393

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Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.PMID 21333004Read ↗

Mutation of epidermal growth factor receptor is associated with MIG6 expression.Semantic proximity Read ↗

Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor.Semantic proximity Read ↗

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Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinomaSemantic proximity Read ↗

Uncovering the Molecular Basis for the Better Gefitinib Sensitivity of EGFR with Complex Mutations over Single Rare Mutation: Insights from Molecular Simulations.Semantic proximity Read ↗

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.Semantic proximity Read ↗

Understanding the MIG6-EGFR Signaling Axis in Lung Tumorigenesis.Semantic proximity Read ↗

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Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor.Semantic proximity Read ↗

Structural Analysis of Interactions between Epidermal Growth Factor Receptor (EGFR) Mutants and Their InhibitorsSemantic proximity Read ↗

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