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Article

Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma.

BMC cancer - 18 Jun 2020

Kang Da Hyun, Jung Sung Soo, Yeo Min-Kyung, Lee Da Hye, Yoo Geon, Cho Sang Yeon, Oh In-Jae, Kim Ju-Ock, Park Hee Sun, Chung Chaeuk, Lee Jeong Eun

Abstract excerpt

BACKGROUND: The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit the kinase activity of epidermal growth factor receptor (EGFR). Similarly, numerous studies of mouse models suggested tumor suppressive function of Mig-6 in lung cancer. On the contrary, the...

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Identifiers

PMID: 32552717
DOI: 10.1186/s12885-020-07057-z
PMCID: PMC7302243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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