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Functional loss of ERBB receptor feedback inhibitor 1 ( MIG6 ) promotes glioblastoma tumorigenesis by aberrant activation of epidermal growth factor receptor ( EGFR )

11 Aug 2024

Abstract excerpt

Dysregulation of epidermal growth factor receptor (EGFR) is one of the most common mechanisms associated with the pathogenesis of various cancers. Mitogen-inducible gene 6 [MIG6; also known as ERBB receptor feedback inhibitor 1 (ERRFI1)], identified as a feedback inhibitor of EGFR, negatively regulates EGFR by directly inhibiting its kinase activity and facilitating its internalization, subsequently leading to...

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PMID: 39129344
DOI: 10.1002/1878-0261.13717

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Functional loss of ERBB receptor feedback inhibitor 1 ( MIG6 ) promotes glioblastoma tumorigenesis by aberrant activation of epidermal growth factor receptor ( EGFR )PMID 39129344Read ↗

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