Article
Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.
Cancer discovery - 1 May 2015
Maity Tapan K, Venugopalan Abhilash, Linnoila Ilona, Cultraro Constance M, Giannakou Andreas, Nemati Roxanne, Zhang Xu, Webster Joshua D, Ritt Daniel, Ghosal Sarani, Hoschuetzky Heinz, Simpson R Mark, Biswas Romi, Politi Katerina, Morrison Deborah K, Varmus Harold E, Guha Udayan
Abstract excerpt
UNLABELLED: Somatic mutations in the EGFR kinase domain drive lung adenocarcinoma. We have previously identified MIG6, an inhibitor of ERBB signaling and a potential tumor suppressor, as a target for phosphorylation by mutant EGFRs. Here, we demonstrate that MIG6 is a tumor suppressor for the initiation and progression of mutant EGFR-driven lung adenocarcinoma in mouse models. Mutant EGFR-induced lung tumor...
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