Article

Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma

2019-09-07

Abstract excerpt

<title>Abstract</title> <p>Background The resistance to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the most important problems in lung cancer field. Mitogen-inducible gene 6 (Mig-6) is known to inhibit the kinase activity of epidermal growth factor receptor (EGFR) and studies of mouse models suggested tumor suppressive function of Mig-6 in lung cancer. On the contrary, the res...

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Literature Corpus work: 396981be-784d-5ce0-a43d-9de8c0a05dc1
DOI: 10.21203/rs.2.14081/v1

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