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Article

Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor.

ACS chemical biology - 15 Nov 2013

Wang Zhihong, Raines Lily L, Hooy Richard M, Roberson Heather, Leahy Daniel J, Cole Philip A

Abstract excerpt

Under physiological conditions, epidermal growth factor receptor (EGFR) tyrosine kinase activity is tightly controlled through the coordinated action of both positive and negative regulators. Aberrant EGFR activation occurs frequently in many cancer types, and the endogenous EGFR feedback inhibitor, Mig6/RALT, is more efficiently phosphorylated by oncogenic EGFR variants. We have utilized expressed protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24004111
DOI: 10.1021/cb4005707
PMCID: PMC3830645

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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