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Article

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Scientific reports - 15 Nov 2024

Teixeira Samantha K, Rossi Fernando P N, Patane José L, Neyra Jennifer M, Jensen Ana Vitória V, Horta Bernardo L, Pereira Alexandre C, Krieger Jose E

Abstract excerpt

Despite the identification of numerous genetic variants affecting SBP in European populations, their applicability in admixed populations remains unclear. This study evaluates the predictive efficacy of a systolic blood pressure (SBP) polygenic risk score (PRS), derived from the UK Biobank data, in two Brazilian cohorts. We analyzed 944 K genetic variants consistent across an independent UK Biobank dataset,...

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Identifiers

PMID: 39548300
DOI: 10.1038/s41598-024-79683-7
PMCID: PMC11568199

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