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Article

Polygenic risk scores associate with blood pressure traits across the lifespan.

European journal of preventive cardiology - 18 Apr 2024

Øvretveit Karsten, Ingeström Emma M L, Spitieris Michail, Tragante Vinicius, Wade Kaitlin H, Thomas Laurent F, Wolford Brooke N, Wisløff Ulrik, Gudbjartsson Daniel F, Holm Hilma, Stefansson Kari, Brumpton Ben M, Hveem Kristian

Abstract excerpt

AIMS: Hypertension is a major modifiable cause of morbidity and mortality that affects over 1 billion people worldwide. Blood pressure (BP) traits have a strong genetic component that can be quantified with polygenic risk scores (PRSs). To date, the performance of BP PRSs has mainly been assessed in adults, and less is known about polygenic hypertension risk in childhood. METHODS AND RESULTS: Multiple PRSs for...

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Identifiers

PMID: 38007706
DOI: 10.1093/eurjpc/zwad365
PMCID: PMC11025038

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DBP

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