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Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy.

Journal of hypertension - 1 Mar 2023

Nurkkala Jouko, Kauko Anni, FinnGen, Laivuori Hannele, Saarela Tanja, Tyrmi Jaakko S, Vaura Felix, Cheng Susan, Bello Natalie A, Aittokallio Jenni, Niiranen Teemu

Abstract excerpt

BACKGROUND: Preexisting hypertension increases risk for preeclampsia. We examined whether a generic blood pressure polygenic risk score (BP-PRS), compared with a preeclampsia-specific polygenic risk score (PE-PRS), could better predict hypertensive disorders of pregnancy. METHODS: Our study sample included 141 298 genotyped FinnGen study participants with at least one childbirth and followed from 1969 to 2021. We...

Topics

Pregnancy
Female
Humans
Pre-Eclampsia
Hypertension, Pregnancy-Induced
Blood Pressure
Risk Factors
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36947680
DOI: 10.1097/HJH.0000000000003336
PMCID: PMC9894151

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