Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating.

American journal of human genetics - 5 Dec 2024

Ma Shiyang, Wang Fan, Border Richard, Buxbaum Joseph, Zaitlen Noah, Ionita-Laza Iuliana

Abstract excerpt

Local genetic correlation analysis is an important tool for identifying genetic loci with shared biology across traits. Recently, Border et al. have shown that the results of these analyses are confounded by cross-trait assortative mating (xAM), leading to many false-positive findings. Here, we describe LAVA-Knock, a local genetic correlation method that builds off an existing genetic correlation method, LAVA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 39547235
DOI: 10.1016/j.ajhg.2024.10.012
PMCID: PMC11639086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating.PMID 39547235Read ↗

Cross-trait assortative mating is widespread and inflates genetic correlation estimatesSemantic proximity Read ↗

Cross-trait assortative mating is widespread and inflates genetic correlation estimates.Semantic proximity Read ↗

XMAP: Cross-population fine-mapping by leveraging genetic diversity and accounting for confounding bias.Semantic proximity Read ↗

An enhanced framework for local genetic correlation analysisSemantic proximity Read ↗

Benchmarking of local genetic correlation estimation methods using summary statistics from genome-wide association studies.Semantic proximity Read ↗

Estimation of inbreeding and kinship coefficients via latent identity-by-descent statesSemantic proximity Read ↗

Robust Inference With Ghostknockoffs in Genome-Wide Association Studies With Sample Relatedness.Semantic proximity Read ↗

A comprehensive meta-analysis of human assortative mating in 22 complex traitsSemantic proximity Read ↗

Family-GWAS reveals effects of environment and mating on genetic associationsSemantic proximity Read ↗

Separating direct, indirect, and parent-of-origin genetic effects in the human population.Semantic proximity Read ↗

Simple models of non-random mating and environmental transmission bias standard human genetics statistical methodsSemantic proximity Read ↗

Testing cross-phenotype effects of rare variants in longitudinal studies of complex traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.