Article
Cross-trait assortative mating is widespread and inflates genetic correlation estimates.
Science (New York, N.Y.) - 18 Nov 2022
Border Richard, Athanasiadis Georgios, Buil Alfonso, Schork Andrew J, Cai Na, Young Alexander I, Werge Thomas, Flint Jonathan, Kendler Kenneth S, Sankararaman Sriram, Dahl Andy W, Zaitlen Noah A
Abstract excerpt
The observation of genetic correlations between disparate human traits has been interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative mating (xAM) as an alternative explanation. We observe that xAM affects many phenotypes and that phenotypic cross-mate correlation estimates are strongly associated with genetic correlation estimates (R2=74%). We demonstrate that existing xAM...
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