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Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson’s disease

14 Nov 2024

Abstract excerpt

Mitochondrial dysfunction plays an important role in Parkinson's disease (PD), with mitochondrial DNA copy number (mtDNA-CN) emerging as a potential marker for mitochondrial health. We investigated the links between blood mtDNA-CN and PD severity and risk using the Accelerating Medicines Partnership program for Parkinson's Disease dataset, replicating our results in the UK Biobank. Our findings reveal that...

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PMID: 39543161
DOI: 10.1038/s41531-024-00831-x

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