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Parkinson’s disease is associated with clonal hematopoiesis with TET2 mutation

6 Sept 2024

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP), a premalignant expansion of mutated hematopoietic stem cells, is linked to immune alterations. Given the role of neuroinflammation and immune dysfunction in Parkinson's disease (PD), we hypothesized a connection between CHIP and PD. We analyzed peripheral blood DNA from 341 PD, 92 isolated REM sleep behavior disorder (iRBD) patients, and 5003 controls using...

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PMID: 39242596
DOI: 10.1038/s41531-024-00784-1

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