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Article

Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease

5 Nov 2015

Abstract excerpt

Like any organ, the brain is susceptible to the march of time and a reduction in mitochondrial biogenesis is a hallmark of the aging process. In the largest investigation of mitochondrial copy number in Parkinson's disease (PD) to date and by using multiple tissues, we demonstrate that reduced Parkinson DNA (mitochondrial DNA mtDNA) copy number is a biomarker for the etiology of PD. We used established methods of...

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PMID: 26639155
DOI: 10.1016/j.neurobiolaging.2015.10.033

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