Article

A mitochondrial blood-based patient stratification candidate biomarker for Parkinson’s disease

2022-02-09

Abstract excerpt

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and neuroprotective interventions remain elusive. High throughput biomarkers aimed to stratify patients based on shared etiology is one critical path to the success of disease-modifying therapies in clinical trials. Mitochondrial dysfunction plays a prominent role in the pathogenesis of PD. Previously, we found brain region-specific mi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45fb0c7b-dfd8-547d-bdf2-edcee4236811
DOI: 10.1101/2022.02.07.479309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A mitochondrial blood-based patient stratification candidate biomarker for Parkinson’s diseaseDOI 10.1101/2022.02.07.479309Read

A blood-based marker of mitochondrial DNA damage in Parkinson’s diseaseSemantic proximity Read

Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease.Semantic proximity Read

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early‐stage Parkinson's diseaseSemantic proximity Read

Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease.Semantic proximity Read

Damage in Mitochondrial DNA Associated with Parkinson's DiseaseSemantic proximity Read

Circulating cell-free mitochondrial DNA levels in Parkinson’s disease are influenced by treatmentSemantic proximity Read

Mitochondrial DNA Deletions Discriminate Affected from Unaffected LRRK2 Mutation CarriersSemantic proximity Read

Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease.Semantic proximity Read

Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson’s diseaseSemantic proximity Read

The role of mitochondrial genetics in Parkinson's disease: Long-read sequencing as an emerging method.Semantic proximity Read

Mitochondrial DNA heteroplasmy distinguishes disease manifestation in <i>PINK1</i>- and <i>PRKN</i>-linked Parkinson’s diseaseSemantic proximity Read

Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's diseaseSemantic proximity Read