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Article

GEM: scalable and flexible gene-environment interaction analysis in millions of samples.

Bioinformatics (Oxford, England) - 25 Oct 2021

Westerman Kenneth E, Pham Duy T, Hong Liang, Chen Ye, Sevilla-González Magdalena, Sung Yun Ju, Sun Yan V, Morrison Alanna C, Chen Han, Manning Alisa K

Abstract excerpt

MOTIVATION: Gene-environment interaction (GEI) studies are a general framework that can be used to identify genetic variants that modify the effects of environmental, physiological, lifestyle or treatment effects on complex traits. Moreover, accounting for GEIs can enhance our understanding of the genetic architecture of complex diseases and traits. However, commonly used statistical software programs for GEI...

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Identifiers

PMID: 34695175
DOI: 10.1093/bioinformatics/btab223
PMCID: PMC8545347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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