Article

Efficient gene-environment interaction tests for large biobank-scale sequencing studies

2020-04-29

Abstract excerpt

<h4>ABSTRACT</h4> Complex human diseases are affected by genetic and environmental risk factors and their interactions. Gene-environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate limiting for large biobank-scale sequencing studies with correlated samples. We propose efficient Mixed-model Association tests for G...

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Literature Corpus work: 9fabb046-f081-5ede-8966-b323f5b79e34
DOI: 10.1101/2020.04.28.067173

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