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Article

A unified method for rare variant analysis of gene-environment interactions.

Statistics in medicine - 15 Mar 2020

Lim Elise, Chen Han, Dupuis Josée, Liu Ching-Ti

Abstract excerpt

Advanced technology in whole-genome sequencing has offered the opportunity to comprehensively investigate the genetic contribution, particularly rare variants, to complex traits. Several region-based tests have been developed to jointly model the marginal effect of rare variants, but methods to detect gene-environment (GE) interactions are underdeveloped. Identifying the modification effects of environmental...

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PMID: 31799744
DOI: 10.1002/sim.8446
PMCID: PMC7261513

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