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Article

DNA methylation biomarkers and myopia: a multi-omics study integrating GWAS, mQTL and eQTL data.

Clinical epigenetics - 13 Nov 2024

Dong Xing-Xuan, Chen Dong-Ling, Chen Hui-Min, Li Dan-Lin, Hu Dan-Ning, Lanca Carla, Grzybowski Andrzej, Pan Chen-Wei

Abstract excerpt

BACKGROUND: This study aimed to identify DNA methylation biomarkers associated with myopia using summary-data-based Mendelian randomization (SMR). METHODS: A systematic search of the PubMed, Web of Science, Cochrane Library, and Embase databases was conducted up to March 27, 2024. SMR analyses were performed to integrate genome-wide association study (GWAS) with methylation quantitative trait loci (mQTL) and...

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Identifiers

PMID: 39538342
DOI: 10.1186/s13148-024-01772-1
PMCID: PMC11562087

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