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Article

Identification of Potential Drug Targets for Myopia Through Mendelian Randomization.

Investigative ophthalmology & visual science - 1 Aug 2024

Qin Yimin, Lei Chengcheng, Lin Tianfeng, Han Xiaotong, Wang Decai

Abstract excerpt

Purpose: The purpose of this study was to identify potential drug targets for myopia and explore underlying mechanisms. Methods: Mendelian randomization (MR) was implemented to assess the effect of 2684 pharmacologically targetable genes in the blood and retina on the risk of myopia from a genomewide association study (GWAS) for age-at-onset of spectacle wearing-inferred mean spherical equivalent (MSE; discovery...

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CD34 gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Protein Interaction Maps

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Identifiers

PMID: 39110588
DOI: 10.1167/iovs.65.10.13
PMCID: PMC11314700

Genes

LCAT
BTN3A1
CD34
CD55
TSSK6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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