Article
MIRAGE: a multimodal deep learning framework for interpretable risk assessment of high myopia from genetic and retinal imaging data.
Human molecular genetics - 9 Jun 2026
Zhou Yijun, Gao Shuaishuai, Wang Tao, Dai Wei, Ye Kaicheng, Ma Bowei, Zhou Yao, Fan Shuyan, Gui Yuanyuan, Ma Wenhao, Chen Zhen Ji, Xing Shilai, Su Jianzhong, Qu Jia, Yuan Jian, Yao Yinghao
Abstract excerpt
High myopia (HM) is a complex condition influenced by both genetic and environmental factors, yet its early prediction and clinical intervention remain challenging due to heterogeneous progression patterns. To support early identification of individuals at risk for HM, we developed MIRAGE, a deep learning framework combining exome-wide genotypes with fundus images for personalized prediction. The model combines...
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