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Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations

30 Dec 2024

Abstract excerpt

High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. Employing a genetic risk score (GRS) is useful for capturing genetic susceptibility to HM. This study assesses the effectiveness of these strategies via incorporating rare variations into the GRS...

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Glaucoma and retinal disorders
Ophthalmology and Visual Impairment Studies
Retinal Diseases and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39738800
DOI: 10.1038/s43856-024-00718-1

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