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Article

Proteome-wide Mendelian randomisation identifies causal links between blood proteins and myopia.

Journal of global health - 20 Feb 2026

Wu Fanye, Zhou Yuehong, Ma Xinyu, Zhao Zhiyuan, Wang Shaoyu, Ma Kedi, Yang Siyu, Cao Mingzhe, Yi Guoguo, Fu Min

Abstract excerpt

Background: Myopia is one of the most prevalent eye diseases worldwide, and its incidence is increasing. However, effective pharmaceutical treatments remain limited. We aimed to identify blood proteins causally associated with myopia as potential drug targets. Methods: We performed a genome-wide association study (GWAS) meta-analysis involving 43 862 myopia cases and 84 820 controls. Then, we conducted a...

Topics

Humans
Mendelian Randomization Analysis
Genome-Wide Association Study
Myopia
Cross-Sectional Studies
Blood Proteins
Proteome
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41718003
DOI: 10.7189/jogh.16.04003
PMCID: PMC12922467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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