Article
A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis.
Cell reports - 26 Nov 2024
Wang Jian, Du Jiajia, Luo Xiangmeng, Guo Linjie, Liu Yixin, Zhou Jianfeng, Zou Yang, Lu Zhenghao, Pan Xiangyu, Chen Xuelan, Zhong Ailing, Wan Xudong, Wang Lu, Liu Hongyu, Dai Siqi, Zhang Shiyu, Xiong Xingyu, Tan Ping, Wang Manli, Wu Baohong, Zhang Qi, Wang Yingjie, Zhang Mengsha, Lu Runda, Lin Huahang, Li Yuan, Li Yaxin, Han Zongkai, Chen Longqi, Hu Bing, Liu Yu, Na Feifei, Chen Chong
Abstract excerpt
Genomics studies have detected numerous genetic alterations in esophageal squamous cell carcinoma (ESCC). However, the functions of these mutations largely remain elusive, partially due to a lack of feasible animal models. Here, we report a convenient platform with CRISPR-Cas9-mediated introduction of genetic alterations and orthotopic transplantation to generate a series of primary ESCC models in mice. With this...
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