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Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Upper aerodigestive squamous cell carcinoma (UASCC) is an aggressive and lethal neoplasm, with its early neoplastic transformation mechanisms remaining poorly understood. Here, we characterize over 25 genetically-defined organoid models derived from murine and human oral/esophageal tissues harboring key driver mutations. Double knockout of TP53 and CDKN2A induced morphological dysplasia, hyper...

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Literature Corpus work
5fd5e905-aa05-586e-ad1c-e898ef5cab7f
DOI
10.1101/2025.01.18.631624
Open publication

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