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Article

A versatile ES cell-based melanoma mouse modeling platform

2019-06-03

Abstract excerpt

The cumbersome and time-consuming process of generating new mouse strains and multi-allelic experimental animals often hinders the use of genetically engineered mouse models (GEMM) in cancer research. Here, we describe the development and validation of an embryonic stem cell (ESC)-GEMM platform for rapid modeling of melanoma in mice. Our platform incorporates twelve clinically relevant genotypes composed of combin...

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Literature Corpus work
c341bb7a-1e6f-58c6-a78c-5ebe4fb214b8
DOI
10.1101/658260
Open publication

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