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Article

An effective multistage mouse model of esophageal carcinogenesis for preclinical and computational pathology applications.

Neoplasia (New York, N.Y.) - 1 Oct 2025

Fu Yuxia, Zhang Guoqing, Liu Yue, Xu Lei, Hu Yuanyuan, Xue Liyan, Guo Huiqin, Fu Yan, Cen Yigang, Li Xiao, Jiang Wei, Yu Xiying

Abstract excerpt

The use of carcinogen-induced multistage carcinogenesis animal models of esophageal squamous cell carcinoma (CIMCM of ESCC) is limited by prolonged timelines, high toxicity, and excessive mutational burden. In this study, we report the establishment of an effective mouse CIMCM of ESCC by using 4-nitroquinoline-1-oxide (4NQO) as a carcinogen and sorafenib (SOR) as a tumor promoter. We show that SOR specifically...

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Identifiers

PMID: 40774225
DOI: 10.1016/j.neo.2025.101217
PMCID: PMC12347694

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