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Article

Genetic landscape of esophageal squamous cell carcinoma.

Nature genetics - 1 Oct 2014

Gao Yi-Bo, Chen Zhao-Li, Li Jia-Gen, Hu Xue-Da, Shi Xue-Jiao, Sun Zeng-Miao, Zhang Fan, Zhao Zi-Ran, Li Zi-Tong, Liu Zi-Yuan, Zhao Yu-Da, Sun Jian, Zhou Cheng-Cheng, Yao Ran, Wang Su-Ya, Wang Pan, Sun Nan, Zhang Bai-Hua, Dong Jing-Si, Yu Yue, Luo Mei, Feng Xiao-Li, Shi Su-Sheng, Zhou Fang, Tan Feng-Wei, Qiu Bin, Li Ning, Shao Kang, Zhang Li-Jian, Zhang Lan-Jun, Xue Qi, Gao Shu-Geng, He Jie

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers. We performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent mutations per tumor, and 8 cell lines. The mutational profile of ESCC closely resembles those of squamous cell carcinomas of other tissues but differs from that of esophageal adenocarcinoma. Genes involved in cell cycle and apoptosis regulation were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25151357
DOI: 10.1038/ng.3076

Genes

AJUBA
CCND1
CREBBP
FAT1
FAT2
FAT3
FAT4
NOTCH1
NOTCH2
NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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