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Article

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion.

Gastroenterology - 1 Sept 2023

Ko Kyung-Pil, Huang Yuanjian, Zhang Shengzhe, Zou Gengyi, Kim Bongjun, Zhang Jie, Jun Sohee, Martin Cecilia, Dunbar Karen J, Efe Gizem, Rustgi Anil K, Nakagawa Hiroshi, Park Jae-Il

Abstract excerpt

BACKGROUND & AIMS: Despite recent progress in identifying aberrant genetic and epigenetic alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC initiation remains unknown. METHODS: Using CRISPR/Cas 9-based genetic ablation, we targeted 9 genes (TP53, CDKN2A, NOTCH1, NOTCH3, KMT2D, KMT2C, FAT1, FAT4, and AJUBA) in murine esophageal organoids. Transcriptomic phenotypes of organoids and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37257519
DOI: 10.1053/j.gastro.2023.05.030
PMCID: PMC10527250

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