Article
A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries.
Disease models & mechanisms - 17 Dec 2019
Veeranki Omkara Lakshmi, Tong Zhimin, Mejia Alicia, Verma Anuj, Katkhuda Riham, Bassett Roland, Kim Tae-Beom, Wang Jing, Lang Wenhua, Mino Barbara, Solis Luisa, Kingsley Charles, Norton William, Tailor Ramesh, Wu Ji Yuan, Krishnan Sunil, Lin Steven H, Blum Mariela, Hofstetter Wayne, Ajani Jaffer, Kopetz Scott, Maru Dipen
Abstract excerpt
Mouse models of gastroesophageal junction (GEJ) cancer strive to recapitulate the intratumoral heterogeneity and cellular crosstalk within patient tumors to improve clinical translation. GEJ cancers remain a therapeutic challenge due to the lack of a reliable mouse model for preclinical drug testing. In this study, a novel patient-derived orthotopic xenograft (PDOX) was established from GEJ cancer via...
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