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Article

Molecular characterization and biomarker identification in paediatric B-cell acute lymphoblastic leukaemia.

Journal of cellular and molecular medicine - 1 Oct 2024

Du Yu, Zhang Xiankai, Sun Ming, Yang Li, Long Fei, Qi Shanshan, Luo Linlin, Lv Xiaoyan, Wang Chenxuan, Wu Xiaoying, Zhu Liuqing, Ou Qiuxiang, Xiong Hao

Abstract excerpt

B-cell acute lymphoblastic leukaemia (B-ALL) is the most prevalent hematologic malignancy in children and a leading cause of mortality. Managing B-ALL remains challenging due to its heterogeneity and relapse risk. This study aimed to delineate the molecular features of paediatric B-ALL and explore the clinical utility of circulating tumour DNA (ctDNA). We analysed 146 patients with paediatric B-ALL who received...

Topics

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Biomarkers, Tumor
Bone Marrow
Circulating Tumor DNA
High-Throughput Nucleotide Sequencing
Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloid-Lymphoid Leukemia Protein

Neoplasm, Residual

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 39384181
DOI: 10.1111/jcmm.70126
PMCID: PMC11464031

Genes

KMT2A
TRIM29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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