Article
A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas.
Molecular cancer therapeutics - 1 Oct 2021
Shah Avanthi Tayi, Azad Tej D, Breese Marcus R, Chabon Jacob J, Hamilton Emily G, Straessler Krystal, Kurtz David M, Leung Stanley G, Spillinger Aviv, Liu Heng-Yi, Behroozfard Inge H, Wittber Frederick M, Hazard Florette K, Cho Soo-Jin, Daldrup-Link Heike E, Vo Kieuhoa T, Rangaswami Arun, Pribnow Allison, Spunt Sheri L, Lacayo Norman J, Diehn Maximilian, Alizadeh Ash A, Sweet-Cordero E Alejandro
Abstract excerpt
Most circulating tumor DNA (ctDNA) assays are designed to detect recurrent mutations. Pediatric sarcomas share few recurrent mutations but rather are characterized by translocations and copy-number changes. We applied Cancer Personalized Profiling by deep Sequencing (CAPP-Seq) for detection of translocations found in the most common pediatric sarcomas. We also applied ichorCNA to the combined off-target reads...
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