Circulating tumour DNA sequencing to determine therapeutic response and identify tumour heterogeneity in patients with paediatric solid tumours.

doi:10.1016/j.ejca.2021.09.042

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Circulating tumour DNA sequencing to determine therapeutic response and identify tumour heterogeneity in patients with paediatric solid tumours.

European journal of cancer (Oxford, England : 1990) - 1 Feb 2022

Stankunaite Reda, George Sally L, Gallagher Lewis, Jamal Sabri, Shaikh Ridwan, Yuan Lina, Hughes Debbie, Proszek Paula Z, Carter Paul, Pietka Grzegorz, Heide Timon, James Chela, Tari Haider, Lynn Claire, Jain Neha, Portela Laura Rey, Rogers Tony, Vaidya Sucheta J, Chisholm Julia C, Carceller Fernando, Szychot Elwira, Mandeville Henry, Angelini Paola, Jesudason Angela B, Jackson Michael, Marshall Lynley V, Gatz Susanne A, Anderson John, Sottoriva Andrea, Chesler Louis, Hubank Michael

Abstract excerpt

OBJECTIVE: Clinical diagnostic sequencing of circulating tumour DNA (ctDNA) is well advanced for adult patients, but application to paediatric cancer patients lags behind. METHODS: To address this, we have developed a clinically relevant (67 gene) NGS capture panel and accompanying workflow that enables sensitive and reliable detection of low-frequency genetic variants in cell-free DNA (cfDNA) from children with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell-Free Nucleic Acids

Share to Child

Share to Circulating Tumor DNA

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Share to Neoplasms

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 34933802
DOI: 10.1016/j.ejca.2021.09.042
PMCID: PMC7617116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating tumour DNA sequencing to determine therapeutic response and identify tumour heterogeneity in patients with paediatric solid tumours.PMID 34933802Read ↗

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumoursSemantic proximity Read ↗

Genomic profiling of circulating tumor DNA for childhood cancers.Semantic proximity Read ↗

Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumorsSemantic proximity Read ↗

Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid TumorsSemantic proximity Read ↗

Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experienceSemantic proximity Read ↗

Single-molecule cfDNA sequencing establishes clinical utility for ecDNA monitoring and multimodal liquid biopsy analysisSemantic proximity Read ↗

Clinical Impact of Ultra-Fast Whole Genome Sequencing in Paediatric Haematology-Oncology PracticeSemantic proximity Read ↗

Detection of tumor-derived cell-free DNA in cerebrospinal fluid using a clinically validated targeted sequencing panel for pediatric brain tumors.Semantic proximity Read ↗

Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden.Semantic proximity Read ↗

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.Semantic proximity Read ↗

Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine.Semantic proximity Read ↗

Circulating cell-free tumor DNA analysis in pediatric cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.