Article
Circulating tumor DNA sequencing of pediatric solid and brain tumor patients: An institutional feasibility study.
Pediatric hematology and oncology - 1 Jan 2023
Mangum Ross, Reuther Jacquelyn, Sen Baksi Koel, Gandhi Ilavarasi, Zabriskie Ryan C, Recinos Alva, Raesz-Martinez Robin, Lin Frank Y, Potter Samara L, Sher Andrew C, Kralik Stephen F, Mohila Carrie A, Chintagumpala Murali M, Muzny Donna, Hu Jianhong, Gibbs Richard A, Fisher Kevin E, Bernini Juan Carlos, Gill Jonathan, Griffin Timothy C, Tomlinson Gail E, Vallance Kelly L, Plon Sharon E, Roy Angshumoy, Parsons D Williams
Abstract excerpt
The potential of circulating tumor DNA (ctDNA) analysis to serve as a real-time "liquid biopsy" for children with central nervous system (CNS) and non-CNS solid tumors remains to be fully elucidated. We conducted a study to investigate the feasibility and potential clinical utility of ctDNA sequencing in pediatric patients enrolled on an institutional clinical genomics trial. A total of 240 patients had tumor DNA...
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