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Article

Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine.

Neuro-oncology - 1 Aug 2022

Pagès Mélanie, Rotem Denisse, Gydush Gregory, Reed Sarah, Rhoades Justin, Ha Gavin, Lo Christopher, Fleharty Mark, Duran Madeleine, Jones Robert, Becker Sarah, Haller Michaela, Sinai Claire E, Goumnerova Liliana, Golub Todd R, Love J Christopher, Ligon Keith L, Wright Karen D, Adalsteinsson Viktor A, Beroukhim Rameen, Bandopadhayay Pratiti

Abstract excerpt

BACKGROUND: The ability to identify genetic alterations in cancers is essential for precision medicine; however, surgical approaches to obtain brain tumor tissue are invasive. Profiling circulating tumor DNA (ctDNA) in liquid biopsies has emerged as a promising approach to avoid invasive procedures. Here, we systematically evaluated the feasibility of profiling pediatric brain tumors using ctDNA obtained from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34984433
DOI: 10.1093/neuonc/noab299
PMCID: PMC9340641

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