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Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors

20 Feb 2023

Abstract excerpt

We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid tumors. A total of 143 plasma samples were analyzed from 19 controls and 73 patients, including 44 bone or soft-tissue sarcomas and 12 renal, 10 germ cell, five hepatic, and...

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PMID: 36805676
DOI: 10.1038/s41698-023-00357-0

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