Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden.

doi:10.1038/s41467-021-23445-w

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Article

Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden.

Nature communications - 28 May 2021

Peneder Peter, Stütz Adrian M, Surdez Didier, Krumbholz Manuela, Semper Sabine, Chicard Mathieu, Sheffield Nathan C, Pierron Gaelle, Lapouble Eve, Tötzl Marcus, Ergüner Bekir, Barreca Daniele, Rendeiro André F, Agaimy Abbas, Boztug Heidrun, Engstler Gernot, Dworzak Michael, Bernkopf Marie, Taschner-Mandl Sabine, Ambros Inge M, Myklebost Ola, Marec-Bérard Perrine, Burchill Susan Ann, Brennan Bernadette, Strauss Sandra J, Whelan Jeremy, Schleiermacher Gudrun, Schaefer Christiane, Dirksen Uta, Hutter Caroline, Boye Kjetil, Ambros Peter F, Delattre Olivier, Metzler Markus, Bock Christoph, Tomazou Eleni M

Abstract excerpt

Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. To unlock liquid biopsy analysis for pediatric tumors with few genetic aberrations, we introduce an integrated genetic/epigenetic analysis method and demonstrate its utility on 241 deep whole-genome...

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Identifiers

PMID: 34050156
DOI: 10.1038/s41467-021-23445-w
PMCID: PMC8163828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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