Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.

Biochimica et biophysica acta - 1 Oct 2009

Shmookler Reis Robert J, Bharill Puneet, Tazearslan Cagdas, Ayyadevara Srinivas

Abstract excerpt

Long-lived mutants provide unique insights into the genetic factors that limit lifespan in wild-type animals. Most mutants and RNA interference targets found to extend life, typically by 1.5- to 2.5-fold, were discovered in C. elegans. Several longevity-assurance pathways are conserved across widely divergent taxa, indicating that mechanisms of lifespan regulation evolved several hundred million years ago. Strong...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene Expression Regulation

Share to Longevity

Share to Models, Biological

Share to Phosphatidylinositol 3-Kinases

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19465083
DOI: 10.1016/j.bbagen.2009.05.011
PMCID: PMC2885961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.PMID 19465083Read ↗

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure-Directed Missense Mutations in the Endogenous AGE-1/Phosphatidylinositol 3-Kinase Catalytic Subunit.Semantic proximity Read ↗

Aging, dauer, and stature phenotypes are conferred by structure-directed missense mutations in the endogenous AGE-1/phosphatidylinositol 3-kinase catalytic subunitSemantic proximity Read ↗

PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans.Semantic proximity Read ↗

Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.Semantic proximity Read ↗

Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling.Semantic proximity Read ↗

Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health spanSemantic proximity Read ↗

Further Extension of Lifespan by Unc-43/CaMKII and Egl-8/PLCβ Mutations in Germline-Deficient Caenorhabditis elegans.Semantic proximity Read ↗

The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans.Semantic proximity Read ↗

Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC‐γ, and IP3R activationSemantic proximity Read ↗

Activated SKN-1 alters the aging trajectories of long-lived Caenorhabditis elegans mutants.Semantic proximity Read ↗

The cell biology of aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.