Article
Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants.
PLoS genetics - 1 May 2022
Hemphill Cassidy, Pylarinou-Sinclair Evye, Itani Omar, Scott Barbara, Crowder C Michael, Van Gilst Marc Ryan
Abstract excerpt
In C. elegans, germline ablation leads to long life span and stress resistance. It has been reported that mutations that block oogenesis or an upstream step in germline development confer strong resistance to hypoxia. We demonstrate here that the hypoxia resistance of sterile mutants is dependent on developmental stage and age. In just a 12-hour period, sterile animals transform from hypoxia sensitive L4 larvae...
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