Article
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis.
PloS one - 1 Jan 2016
Fransén-Pettersson Nina, Duarte Nadia, Nilsson Julia, Lundholm Marie, Mayans Sofia, Larefalk Åsa, Hannibal Tine D, Hansen Lisbeth, Schmidt-Christensen Anja, Ivars Fredrik, Cardell Susanna, Palmqvist Richard, Rozell Björn, Holmberg Dan
Abstract excerpt
Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration...
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