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Clinical characteristics, genomic profiling, treatments, and outcomes of Langerhans cell sarcoma.

Orphanet journal of rare diseases - 20 Jan 2026

Lang Min, Zheng Xiao-Juan, Chang Long, Zhou Dao-Bin, Zhang Wei, Cao Xin-Xin

Abstract excerpt

BACKGROUND: Langerhans cell sarcoma (LCS), an exceptionally rare and aggressive neoplasm, remains poorly characterized due to its scarcity. To address this knowledge gap, we conducted a retrospective analysis of 13 LCS patients. This retrospective study included patients ≥ 18 years old with biopsy proven LCS from October 2015 to April 2025. RESULTS: The median age at diagnosis was 59 years (range: 33–71). The...

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PMID: 41559709
DOI: 10.1186/s13023-026-04199-4
PMCID: PMC12903575

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CBL

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