Article
Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments.
Journal of molecular biology - 28 Aug 2015
Oztug Durer Zeynep A, McGillivary Rebecca M, Kang Hyeran, Elam W Austin, Vizcarra Christina L, Hanein Dorit, De La Cruz Enrique M, Reisler Emil, Quinlan Margot E
Abstract excerpt
Vinculin is an abundant protein found at cell-cell and cell-extracellular matrix junctions. In muscles, a longer splice isoform of vinculin, metavinculin, is also expressed. The metavinculin-specific insert is part of the C-terminal tail domain, the actin-binding site of both isoforms. Mutations in the metavinculin-specific insert are linked to heart disease such as dilated cardiomyopathies. Vinculin tail domain...
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