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Article

Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells.

Molecular cancer research : MCR - 6 Feb 2025

Clevenger Abigail J, Collier Claudia A, Gorley John Paul M, Colijn Sarah, McFarlin Maygan K, Solberg Spencer C, Kopetz Scott, Stratman Amber N, Raghavan Shreya A

Abstract excerpt

Colorectal cancer tumors start as polyps on the inner lining of the colorectum, in which they are exposed to the mechanics of peristalsis. Our previous work leveraged a custom-built peristalsis bioreactor to demonstrate that colonic peristalsis led to cancer stem cell enrichment in colorectal cancer cells. However, this malignant mechanotransductive response was confined to select colorectal cancer lines that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39485528
DOI: 10.1158/1541-7786.MCR-24-0624
PMCID: PMC11802306

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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